Abstract
The synthesis and in vitro structure-activity relationships (SAR) of a series of triazoles as A(2A) receptor antagonists is reported. This resulted in the identification of potent, selective and permeable 1,2,4-triazoles such as 42 for further optimization and evaluation in vivo.
MeSH terms
-
Adenosine A2 Receptor Antagonists*
-
Animals
-
Cell Membrane / chemistry*
-
In Vitro Techniques
-
Molecular Structure
-
Rats
-
Structure-Activity Relationship
-
Triazoles / chemical synthesis*
-
Triazoles / pharmacology*
Substances
-
Adenosine A2 Receptor Antagonists
-
Triazoles
-
1,2,4-triazole